COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics.
Identifieur interne : 000B27 ( Main/Exploration ); précédent : 000B26; suivant : 000B28COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics.
Auteurs : Kuldeep Dhama [Inde] ; Khan Sharun [Inde] ; Ruchi Tiwari [Inde] ; Maryam Dadar [Iran] ; Yashpal Singh Malik [Inde] ; Karam Pal Singh [Inde] ; Wanpen Chaicumpa [Thaïlande]Source :
- Human vaccines & immunotherapeutics [ 2164-554X ] ; 2020.
Abstract
The novel coronavirus infection (COVID-19 or Coronavirus disease 2019) that emerged from Wuhan, Hubei province of China has spread to many countries worldwide. Efforts have been made to develop vaccines against human coronavirus (CoV) infections such as MERS and SARS in the past decades. However, to date, no licensed antiviral treatment or vaccine exists for MERS and SARS. Most of the efforts for developing CoV vaccines and drugs target the spike glycoprotein or S protein, the major inducer of neutralizing antibodies. Although a few candidates have shown efficacy in in vitro studies, not many have progressed to randomized animal or human trials, hence may have limited use to counter COVID-19 infection. This article highlights ongoing advances in designing vaccines and therapeutics to counter COVID-19 while also focusing on such experiences and advances as made with earlier SARS- and MERS-CoVs, which together could enable efforts to halt this emerging virus infection.
DOI: 10.1080/21645515.2020.1735227
PubMed: 32186952
Affiliations:
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(COVID-19 or Coronavirus disease 2019) that emerged from Wuhan, Hubei province of China has spread to many countries worldwide. Efforts have been made to develop vaccines against human coronavirus (CoV) infections such as MERS and SARS in the past decades. However, to date, no licensed antiviral treatment or vaccine exists for MERS and SARS. Most of the efforts for developing CoV vaccines and drugs target the spike glycoprotein or S protein, the major inducer of neutralizing antibodies. Although a few candidates have shown efficacy in <i>in vitro</i> studies, not many have progressed to randomized animal or human trials, hence may have limited use to counter COVID-19 infection. This article highlights ongoing advances in designing vaccines and therapeutics to counter COVID-19 while also focusing on such experiences and advances as made with earlier SARS- and MERS-CoVs, which together could enable efforts to halt this emerging virus infection.</div></front></TEI><affiliations><list><country><li>Inde</li><li>Iran</li><li>Thaïlande</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Dhama, Kuldeep" sort="Dhama, Kuldeep" uniqKey="Dhama K" first="Kuldeep" last="Dhama">Kuldeep Dhama</name></noRegion><name sortKey="Malik, Yashpal Singh" sort="Malik, Yashpal Singh" uniqKey="Malik Y" first="Yashpal Singh" last="Malik">Yashpal Singh Malik</name><name sortKey="Sharun, Khan" sort="Sharun, Khan" uniqKey="Sharun K" first="Khan" last="Sharun">Khan Sharun</name><name sortKey="Singh, Karam Pal" sort="Singh, Karam Pal" uniqKey="Singh K" first="Karam Pal" last="Singh">Karam Pal Singh</name><name sortKey="Tiwari, Ruchi" sort="Tiwari, Ruchi" uniqKey="Tiwari R" first="Ruchi" last="Tiwari">Ruchi Tiwari</name></country><country name="Iran"><noRegion><name sortKey="Dadar, Maryam" sort="Dadar, Maryam" uniqKey="Dadar M" first="Maryam" last="Dadar">Maryam Dadar</name></noRegion></country><country name="Thaïlande"><noRegion><name sortKey="Chaicumpa, Wanpen" sort="Chaicumpa, Wanpen" uniqKey="Chaicumpa W" first="Wanpen" last="Chaicumpa">Wanpen Chaicumpa</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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